Manual Protocols for Oligonucleotides and Analogs: Synthesis and Properties

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And several new oligonucle otide analogs have been synthesized and studied for their individual prop erties in recent years. The present volume strives to bring the readers the most up-to-date information on the newest aspects of synthesis of oligo nucleotides and their analogs.

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A separate volume covers synthesis of oligonucleotide conjugates, along with most of the analytical techniques presently used for analysis of oligonucleotides. Oligonucleotide Synthesis Phosphotriester Approach. Oligodeoxyribonucleotides Synthesis Phosphoramidite Approach. Oligodeoxynucleotide Synthesis HPhosphonate Approach. Synthesis of 20ALkyloligoribonucleotides. Vasulinga T.

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Protocols for oligonucleotides and analogs : Synthesis and properties

Abstract A triester method for the synthesis of deoxynucleoside phosphorodithioate dimers is described. Open in new tab Download slide. Issue Section:. Download all figures. Comments 0. Add comment Close comment form modal. I agree to the terms and conditions.

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View Metrics. Email alerts New issue alert. Oligonucleotide Synthesis: Phosphotriester Approach. Oligodeoxyribonucleotide Synthesis: Phosphoramidite Approach. Oligodeoxynucleotide Synthesis: H-Phosphonate Approach. Synthesis of 2'-O-Alkyloligoribonucleotides. Oligonucleoside Phosphorothioates. Oligodeoxyribonucleotide Phosphotriesters. Oligonucleoside Boranophosphate Borane Phosphate.

Oligonucleotide Phosphorofluoridates and Fluoridates. Oligonucleotide Analogs Containing Dephosphointernucleoside Linkages. Scaleup of Oligonucleotide Synthesis: Solution Phase.


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  6. Solid-Phase Supports in Oligonucleotide Synthesis. The protocols presented cover all DNA analogs that have been studied to date and constitute the single most extensive source of knowledge about DNA chemistry available. Bibliographic information.